The Guardians got a stellar start to edge the White Sox 5-3 in Chicago.
Joey Cantillo mowed down 10 batters and gave up one run on two hits over seven innings to earn the win.
Bo Naylor and David Fry slugged solo shots as Cleveland snapped a two-game skid and remains three-and-a-half games ahead of the Royals for first place in the AL Central.
The three-game set continues tonight.